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Silicon dioxide inhibits STING1. 3 / 3
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"When DNase I is used to degrade dsDNA, silica-induced STING activation and the downstream type-I-IFN response are inhibited (Benmerzoug et al., 2018)."
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"Furthermore, intraperitoneal administration of DNase I in mice has been found to prevent silica-induced accumulation of self-DNA in the airways, reducing silica-induced STING-dependent lung proinflamm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Degradation of extracellular self-dsDNA by DNase I inhibits silica induced STING activation and the downstream type I IFN response."
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