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SCN5A activates apoptotic process. 8 / 8
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"Up-regulation of SCN5A inhibited MDR in HL-60 cells, enhanced the chemosensitivity of HL-60/ADR, and increased the apoptosis levels of HL-60 and HL-60/ADR cells."
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"For instance, depletion of hH1.2 induces apoptosis in MCF7 cells, which are p53-positives, while it results in G1 arrest in T47D cells, which are p53 negative."
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"Overexpression of SCN5A overcomes ABC transporter-mediated multidrug resistance in acute myeloid leukemia through promoting apoptosis."
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"This finding aligns with another investigation indicating that Nav1.5 augments 5-Fluorouracil-stimulated apoptosis in colorectal cancer cells [46]."
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"The objective of this work is to study embryo development and blastomere apoptosis of biopsied and non biopsied-derived embryos produced by ICSI and IVF of prepubertal goat oocytes with different diam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We further noted that the higher proportions of day 15 conceptuses with shorter EET length and a round embryonic disk were recovered when IVM/IVF cultures were performed under PTGS2 inhibition using 8 μM NS-398, or in other words IVM/IVF conditions inducing a higher incidence of embryonic apoptosis at the blastocyst stage."
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"LQTS Mutation N1325S in Cardiac Sodium Channel Gene SCN5A Causes Cardiomyocyte Apoptosis, Cardiac Fibrosis and Contractile Dysfunction in Mice."
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"29 CCs from advanced‐age patients undergoing IVF present increased apoptosis and are related to remarkably lower fertilization and pregnancy rates."
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