IndraLab

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USP8 deubiquitinates RNF128. 2 / 2

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"These data further demonstrate that the two isoforms of Otubain 1 have opposing effects on GRAIL and that Otubain 1 ARF-1 recruits the ubiquitin specific protease 8 (USP-8) to promote GRAIL deubiquitination and stabilization."

24917867

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"This unexpected function of otubain-1 might be mediated through the inhibition of USP8, a DUB that binds to and deubiquitylates GRAIL; however, it is not known how otubain-1 might inhibit USP8."

18535581

INDRA sources:

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IndraLab

Statements

USP8 deubiquitinates RNF128. 2 / 2

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