IndraLab

Statements

CYLD inhibits IRF3. 3 / 3
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"Interestingly, CYLD is a negative regulator of the RIG-I and MAVS pathway as silencing of CYLD enhances the IRF3 response to sendai virus."
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"Ectopic expression of CYLD inhibits the IRF3 signalling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances the response."
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"For example, CYLD removes polyubiquitin chains from TBK1 and RIG-I and thus inhibits the IRF3 signaling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances this response (58)."
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