IndraLab

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Mice inhibits OTUD7B. 4 / 4
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"Both AAV9-shNC and AAV9-shOTUD7B mice showed significant reductions in HNF4α levels after TAC when compared to sham groups Moreover, OTUD7B knockdown mice exhibited a more robust decrease in HNF4α expression following TAC compared to AAV9-shNC mice (Fig. 5E, F)."
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"Representative heart images further demonstrated enlarged hearts in OTUD7B knockdown mice compared to wild-type controls post-TAC (Fig. 2D)."
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"Body weight remained unchanged across the four groups (Figure S2A); however, heart weight, along with heart weight/body weight (HW/BW) and heart weight/tibia length (HW/TL) ratios, significantly increased in OTUD7B knockdown mice after TAC (Figure S2B, 2E, F)."
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"Concordant with the histological and echocardiographic findings, protein levels of BNP (brain natriuretic peptide), COL3A1 (collagen type III alpha 1), and mRNA expressions of Bnp, Myh7 (myosin heavy chain 7), and Col3a1 were markedly elevated in OTUD7B knockdown mice post-TAC (Fig. 2N, O)."
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