IndraLab

Statements

FANCD2 activates USP1. 4 / 4
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"Deubiquitylation of FANCD2 and FANCI is mediated by the ubiquitin specific peptidase 1 (USP1) and USP1 associated factor 1 (UAF1; also known as WDR48) complex 73."
21863050
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"USP1 targets FANCD2, FANC1, and PCNA for deubiquitylation."
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"However, pathway (s) responsible for the regulation of USP1 as well as the molecular mechanism by which USP1 regulates DDR in beta-cells, especially in the diabetic environment, remains unknown and wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In USP1 depleted cells this fraction is also enriched in SQSTM1 (sequestosome 1), the aggresome marker HDAC6 (histone deacetylase 6), and the prototype of USP1 targets FANCD2 (FA complementation group D2)."
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