IndraLab

Statements

FANCD2 activates USP1. 4 / 4
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"To achieve this, we depleted USP1 in HeLa FANCD2 cells stably expressing EGFP-FANCD2, EGFP-FANCD2-10A, and EGFP-FANCD2-10D and assessed the impact on the monoubiquitination status of these proteins.As expected, depleting USP1 led to an increase of monoubiquitinated EGFP-FANCD2 (Figure 6C, lane 3), which was further increased when ICLs were introduced in cells (Figure 6C, lane 4)."
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"USP1 targets FANCD2, FANC1, and PCNA for deubiquitylation."
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"Deubiquitylation of FANCD2 and FANCI is mediated by the ubiquitin specific peptidase 1 (USP1) and USP1 associated factor 1 (UAF1; also known as WDR48) complex 73."
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"In USP1 depleted cells this fraction is also enriched in SQSTM1 (sequestosome 1), the aggresome marker HDAC6 (histone deacetylase 6), and the prototype of USP1 targets FANCD2 (FA complementation group D2)."
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