IndraLab

Statements

BAP1 activates Neoplasms. 33 / 33
| 33
reach
"Through a biochemical screen, we identified BAP1 catalytic inhibitors that inhibit truncated-ASXL1-driven leukemic gene expression and impair tumor progression in vivo."
35122023
reach
"Therefore, it will be important to investigate the mechanism underlying the tumor-promoting effect of BAP1 inactivation in each cell type.In summary, this study demonstrated that Bap1 loss promotes tumorigenesis only in the tissues in which Bap1 is not engaged in pro-survival gene expression, providing an explanation for the tissue specificity of the BAP1 cancer predisposition syndrome."
35117145
reach
"Pathogenic germline variants in the BRCA1-associated protein 1 (BAP1) gene cause a dominantly inherited tumor predisposition syndrome, BAP1-TPDS, in which MM is the second most common associated cancer."
35114507
reach
"Tumor suppressor BAP1 (BRCA1-associated protein 1) promotes ferroptosis and inhibits tumor development via a similar mechanism [92]."
38203246
reach
"Germline or somatic mutations and deletions of BAP1 have been identified in various tumor types, and downregulation or inactivation of BAP1 could accelerate tumor onset, invasion, recurrence, and metastases ."
30305612
reach
"The results showed that knocked down BAP1 rescued the promoting effect of overexpressed KLF5 on volume and weight of tumor in nude mice ( Fig. 5 E)."
33516665
reach
"Significantly, it was recently revealed that xCT is involved in tumor initiation as it is directly repressed by p53 or BAP1 as a means to exert tumor suppression (27, 28)."
31000598
reach
"Pathogenic germline variants in the BRCA1-Associated Protein 1 (BAP1) tumor suppressor gene cause a rare, life-threatening tumor predisposition syndrome (BAP1-TPDS, OMIM 614327) also known as BAP1 cancer syndrome as the majority of carriers develop malignancy [1, 2]."
37956408
reach
"By contrast, BAP1-driven tumors showed higher levels of immune infiltration, especially by myeloid cells, with low levels of endothelial cells."
| PMC
reach
"Furthermore, BAP1 germline mutations cause a tumor predisposition syndrome inherited in an autosomal dominant pattern, which confers a higher risk for developing a spectrum of benign and malignant tumors , including pancreatic cancer ."
32541668
reach
"BAP1 depletion inhibits the growth of colon tumors in xenograft mice."
36754982
reach
"Our data also showed that BAP1 depletion inhibited colon cancer cell proliferation and tumor growth."
36754982
reach
"The findings are in accordance with previous reports that reduced expression or inactivation of BAP1 in tumors, which often results from germline-inactivating or somatic-inactivating BAP1 mutations or deletions, increases tumor susceptibility, or predicts worse clinical outcomes ."
30305612
reach
"This suggests that Bap1 may contribute to shaping the tumor immune microenvironment through the regulation of the innate immune response.Taken together, the multi-omics analysis reveals that Bap1 deletion leads to multiple changes within tumor cells, resulting in a cDC1-CD8 T cell-mediated cytotoxicity in an immune-stimulatory tumor microenvironment."
39141316
reach
"In mutant ASXL1-driven leukemia models, inhibition of BAP1 by small molecule inhibitors could significantly reduce tumor burden and extend animal survival (50)."
34341073
reach
"Histological and clinical comparison of fusion-driven versus BAP1-driven FLC tumors indicated steatosis phenotypes specifically prominent in the BAP1-related tumors ."
37137901
reach
"Moreover, BAP1 was found to stabilize the transcription factor KLF5 and subsequently promoted the breast cancer cell proliferation and tumor growth in vitro and in vivo [23]."
37543638
reach
"Whereas the tumor suppressive role has been attributed to BAP1’s important involvement in DNA double strand breakage repair [37], there is emerging evidence that BAP1 can also promote tumor growth when it is overexpressed in particular molecular environments."
31903168
reach
"BAP1 tumor predisposition syndrome is caused by pathogenic germline variants in the BAP1 tumor suppressor gene and characterized by a predisposition to various tumors including meningioma."
35969220
reach
"In addition, a mutation in the BRCA1-associated protein-1 (BAP1) gene is implicated in UM metastasis, and is also known to promote the development of cutaneous melanoma, basal cell carcinoma, malignan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32926921
reach
"Furthermore, we observed that BaP1 decreased angiogenesis, characterized by a significant decrease in the vascularization formed around the tumors, as well as reduced tumor proliferation evidenced by the reduced levels of Ki67 expression in the tumors treated with the compound.Overall, our data highlights BaP1 as a molecule with a potent and selective anticancer activity against CRC cells and as a very interesting agent to disturb and counteract the important roles of lysosome in cancer."
36614056
reach
"Recent work has shown that BAP1 biallelic inactivation could promote metastasis development by enhancing immune evasion of the tumor through inhibition of the immune response [15], consistent with the limited response of UM to immunotherapy [9]."
37958591
reach
"This raises the possibility for genetic cooperation with BAP1-driven pathogenicity in tumor B, but this particular mutation has not been previously noted to be pathogenic.At present, more than 7 years post- resection, Patient A has no clinical or radiographic evidence of newly recurrent or progressive disease."
34504799
reach
"Germline loss-of-function variants in the BRCA1-associated protein 1 gene (BAP1) cause an autosomal dominant tumor predisposition syndrome, with most such variants generating frameshift or truncating alleles, yet >1,000 missense variants have been clinically observed to date."
38969833
reach
"The transcriptomic FLC signature, by capturing dysregulations independent of the experimental processing and characteristic of FLC tumors, empowers identifying which FLC-like tumors cluster with DNAJB1::PRKACA and which, such as the BAP1-driven tumors, do not."
39738196
reach
"Here, we show that BAP1 is upregulated in colon cancer cells and tissues and that BAP1 depletion reduces colon cancer cell proliferation and tumor growth."
36754982
reach
"Germline mutations in BAP1 are known to cause a tumor predisposition syndrome, which is accompanied by the risk of early onset of several malignancies, such as (uveal) melanoma, renal cancer, and PeM."
37453150
reach
"Moreover, BAP1 is a DUB for the transcription factor KLF5 and depletion of BAP1 inhibits breast cancer cell proliferation and tumor growth in vitro and in vivo in an KLF5-dependent manner [23]."
37543638
reach
"This indicates that BAP1 function loss inhibits TGF-β secretion in PE, thus implying that BAP1 alterations affect the EMT and tumor immunoescape , although its clinical significance remains unknown."
38987362
reach
"We showed that BAP1 is upregulated in colon cancer cells and tissues and that BAP1 depletion reduces colon cancer cell proliferation and tumor growth."
36754982
reach
"Meanwhile, the stability and expression of SLC7A11 is affected by OUTB1 and BAP1 to promote or inhibit tumor ferroptosis [128, 129]."
38575922
reach
"Having survived BAP1 loss, those precancerous cells in melanocytic tissue and mesothelium are poised to respond to additional tumor-promoting effects of BAP1 inactivation.In fact, He et al. also provided insight into the tumor-promoting effect of BAP1 inactivation in melanocytes (1)."
35117145
reach
"Given the diversity of the cellular processes that BAP1 regulates and the possibility that BAP1 influences expression of many target genes, it is possible that the tumor-promoting effect of BAP1 inactivation is also tissue-specific."
35117145