IndraLab

Statements

USP15 increases the amount of CTNNB1. 4 / 4
| 4
reach
"In our study, knockdown of USP15 significantly reduced the nuclear expression of β-catenin and downregulation of Wnt/β-catenin downstream genes in GC cells, while USP15 overexpression yielded opposite results, and there was no change in the USP15 C269S group (USP15 mutant), indicating that USP15 acted as a Wnt/β-catenin pathway activator."
34326621
reach
"Furthermore, silence of USP15 or PRPF19 in ABHD11-AS1-overexpressing HCC15 cells also reduced CD44, CD44v6, total and active β-catenin levels, and these effects were partially reversed by CD44v6 overexpression (Fig. 8d)."
38364571
reach
"In addition, knockdown of USP15 or PRPF19 drastically decreased CD44, CD44v6, total and active β-catenin levels in A549 cells."
38364571
reach
"In addition, USP15 knockdown significantly reduced the protein levels of β-catenin, c-myc, and cyclin D1 in tumor tissue of nude mouse, consistent with the in vitro results (Figure 6D)."
34326621