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TFAP4 activates USP15. 5 / 5
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"Moreover, the activation of USP15 by TFAP4 as a transcription factor was validated by the following ChIP and pull‐down assay, which would provide a novel theoretical basis for a deeper understanding of renal carcinogenesis.Collectively, our study demonstrated that USP15 upregulation accelerates ccRCC malignant behavior, which may attributed to increased SHC1 stabilization via deubiquitination."
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"Moreover, the activation of USP15 by TFAP4 as a transcription factor was validated by the following ChIP and pull‐down assay, which would provide a novel theoretical basis for a deeper understanding of renal carcinogenesis."
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"We concluded that USP-15 promoted the malignant phenotypes of CRC cells by the deubiquitination of TFAP4 upon the transcriptionally activation of PCGF1."
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"These data implied that TFAP4 transcriptionally upregulated the PCGF1 expression.We further investigate whether TFAP4 mediated the pro-tumor effects of USP-15."
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"USP15, activated by TFAP4 transcriptionally, stabilizes SHC1 via deubiquitination and deteriorates renal cell carcinoma."
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