IndraLab

Statements

OTUB1 is methylated on K122. 9 / 9
| 9
sparser
"Here, we demonstrate that SET7, a lysine monomethylase, directly interacts with OTUB1 to catalyze OTUB1 methylation at lysine 122."
36822329
sparser
"Subsequently, we sought to know whether SET7-mediated methylation of OTUB1 at K122 could affect OTUB1 protein stability."
36822329
sparser
"Subsequently, we examined whether OTUB1 methylation at K122 was mediated by SET7."
36822329
sparser
"Moreover, SETD7, a lysine monomethylase, directly interacts with OTUB1 to catalyze the methylation of OTUB1 at Lys 122, disrupting the interaction between OTUB1 and the anti -ferroptosis protein ubiquitin conjugating enzyme E2 N (UBE2N/UBC13) in H1299 lung cancer cells [ xref ]."
38955112
sparser
"As reported previously, phosphorylation of OTUB1 at Serine 16 by Casein kinase 2 causes nuclear accumulation of OTUB1 ( xref ), we sought to know whether SET7-mediated methylation of OTUB1 at K122 could alter subcellular localization of OTUB1."
36822329
sparser
"Here, we identified that SET7-catalyzed lysine methylation of OTUB1 at K122 resulted in specifically inhibiting the noncanonical activity, but not the enzymatic activity of OTUB1."
36822329
sparser
"SET7 directly interacts with OTUB1 to methylate OTUB1 on lysine 122."
36822329
sparser
"SETD7, a lysine monomethylase, directly interacts with ubiquitin thioesterase 1 (OTUB1) to catalyse OTUB1 methylation at Lys 122, disrupting the interaction between OTUB1 and the anti-ferroptosis protein ubiquitin conjugating enzyme E2 N (UBE2N/UBC13) in H1299 lung cancer cells xref ."
41233346
sparser
"Given that OTUB1 is a typical deubiquitinase, we initially sought to know whether SET7-mediated methylation of OTUB1 at K122 could affect deubiquitinase activity of OTUB1."
36822329