IndraLab

Statements

Gallic acid inhibits STAT1. 9 / 9
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"Notably, our study indicated that pretreatment with GA is able to suppress the induction of IRF-1 by inhibiting the activation of STAT1."
24657155
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"GA also reduces the activation of STAT1 and STAT3 by MS-associated stimuli such as IFN-γ or LPS in the primary glia."
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"These findings suggest that GA is able to inhibit the activation of STAT1 ( Fig. 4 A)."
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"These results suggest that GA could inhibit the activations of STAT1 and -3 in PBMCs, in addition to brain resident immune cells."
28094337
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"GA is able to inhibit cell proliferation by suppressing Wnt/β-catenin signaling [113] and inhibiting the transcription factors AP-1, NF-kb, STAT1, and OCT-1 [54] in HCT-116, HCT-15, and Caco-2 cell models."
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"GA attenuates the STAT1 and -3 signaling in peripheral blood mononuclear cells, but not neuronal cells."
28094337
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"Cotreatment with 18βGA at 50 and 100 mg/kg significantly reduced oxidative brain damage, inflammation, apoptosis, ER stress, and JAK1/STAT1 signaling [74]."
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"These results indicate that the ability of GA to inhibit the activations of STAT1 and -3 is not mediated through IFNgamma -/- or IFNgammaR -/- system."
28094337
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"Glatiramer acetate (GA), a FDA approved treatment for MS, was shown to promote activation of anti-inflammatory monocytes by reducing STAT1 signaling."
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