
IndraLab
Statements
reach
"Since IHNV NV also interacts with PPM1Bb, recruits it in close vicinity to mitochondria and strongly inhibits the RIG-I pathway of interferon induction, it can be speculated that IHNV NV could redirect PPM1Bb phosphatase to another substrate such as IRF3 or DDX3 which are phosphorylated by TBK1 and involved downstream it in the RLR signaling."