IndraLab

Statements

Tacrolimus (anhydrous) inhibits NFKB1. 7 / 7
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"FK506 inhibits the nuclear factor of activated T cells (NF-AT) and NF-KB activation in T lymphocytes, suggesting that different tissues may respond differently to NF-KB inhibitors."
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"The immunosuppressant FK506 activates NF-KB in fibroblasts and renal mesangial cells, which may be the mechanism underlying the nephrotoxic effects of this agent [35]."
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"Research findings show that the chronic administration of tacrolimus significantly reduces spontaneous optic neuropathy in p50 deficient mice."
21850191
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"FK506 caused a 30-40% reduction in nuclear p65 and a more pronounced reduction (70-80%) of nuclear cRel, p50, and NFATc."
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"Pre-treatment with tacrolimus markedly protected RGC-5 cells from NMDA induced neurotoxicity, and then both spontaneous RGC death and degenerative changes to the optic nerve in p50 deficient mice were significantly reduced by the chronic administration of tacrolimus."
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"Furthermore, FK506 inhibited nuclear factor-kappaB activation and decreased mRNA levels of the p50 and p65 subunits of nuclear factor-kappaB."
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"Tacrolimus also inhibits the activation of NFkB, which is strongly connected with the generation of ROS."
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