IndraLab

Statements

Tacrolimus (anhydrous) inhibits NFKB1. 7 / 7
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"Furthermore, FK506 inhibited nuclear factor-kappaB activation and decreased mRNA levels of the p50 and p65 subunits of nuclear factor-kappaB."
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"Finally, at the nuclear level, tacrolimus specifically prevents NF-κB subunits RelA, p50, c-Rel and other members from entering the nucleus [150] ."
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"Tacrolimus also inhibits the activation of NFkB, which is strongly connected with the generation of ROS."
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"Research findings show that the chronic administration of tacrolimus significantly reduces spontaneous optic neuropathy in p50 deficient mice."
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"The immunosuppressant FK506 activates NF-KB in fibroblasts and renal mesangial cells, which may be the mechanism underlying the nephrotoxic effects of this agent [35]."
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"FK506 inhibits the nuclear factor of activated T cells (NF-AT) and NF-KB activation in T lymphocytes, suggesting that different tissues may respond differently to NF-KB inhibitors."
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"FK506 caused a 30-40% reduction in nuclear p65 and a more pronounced reduction (70-80%) of nuclear cRel, p50, and NFATc."
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