IndraLab

Statements

Divinyl sulfone inhibits NLRP3. 4 / 4
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"Bay 11-7082 is a multi-functional phenyl vinyl sulfone that inhibits the NLRP3 inflammasome independently of its inhibitory activity on NF-κB and IKK-β (Juliana et al., 2010)."
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"Both vinyl sulfones could inhibit the ATPase activity of NLRP3 in vitro and demonstrate direct interaction under those conditions ; however , they are each broad-spectrum inhibitors active against multiple targets in inflammatory responses [ 196,197 ] ."
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"Bay 11-7082, a phenyl vinyl sulfone related compound, was shown to prevent the organization of the ASC pyroptosome and NLRP3 inflammasome through alkylation of cysteine residues in the ATPase region of NLRP3."
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"Known for their anti-inflammatory properties, natural products such as Oridonin (found in Rabdosia rubescens plant) and Parthenolide (sesquiterpene lactone found in feverfew plant) as well as synthetic compound Bay 11-7082 and related vinyl sulfone compounds have been shown to exert their effects via inhibition of the NLRP3 inflammasome."
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