IndraLab

Statements

Divinyl sulfone inhibits NLRP3. 4 / 4
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"Bay 11-7082, a phenyl vinyl sulfone related compound, was shown to prevent the organization of the ASC pyroptosome and NLRP3 inflammasome through alkylation of cysteine residues in the ATPase region of NLRP3."
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"The vinyl sulfone BAY 11 - 7082 , selectively inhibited activation of the NLRP3 inflammasome targeting its ATPase activity in an irreversible way."
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"Bay is a phenyl vinyl sulfone that inhibits the NF-kB pathway by blocking the kinase activity of IKBKB and inhibiting the NLRP3 inflammasome [13,14]."
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"The vinyl sulfone Bay 11-7082, the sesquiterpene lactone parthenolide, and the benzoxathiole derivative BOT-4-one all block the ATPase activity of NLRP3 [116,117]."
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