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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BAP1 inhibits PRC2_complex. 2 / 2

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"Loss of BAP1 has been shown to be synthetically lethal with inhibition of EZH2 or PRC2."

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"As for the reported tumor suppressive mechanism, BAP1 can antagonize EZH2 and PRC2 or RING1B (RNF2)/PRC1 in a tissue specific manner."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...