IndraLab

Statements

BAP1 inhibits PRC2_complex. 6 / 6
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"BAP1 loss induces PRC2-mediated transcriptional repression in mouse and human mesothelioma."
36657447
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"It has been proposed that the loss of BAP1 promotes PRC2 activity and that the cells that lack BAP1 are sensitive to EZH2 inhibition."
27742591
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"In mouse models, the loss of BAP1 leads to elevated enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) expression and enhanced repression of polycomb repressive complex 2 (PRC2) targets [48]."
38136262
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"In MPM cell lines, BAP1 loss was observed to be related to increased EZH2 expression and enhanced repression of PRC2-regulated targets."
37298116
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"As for the reported tumor suppressive mechanism, BAP1 can antagonize EZH2 and PRC2 or RING1B (RNF2)/PRC1 in a tissue specific manner."
32269030
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"Loss of BAP1 has been shown to be synthetically lethal with inhibition of EZH2 or PRC2."
30030490