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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP16 leads to the phosphorylation of NFKB1. 8 / 8

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"USP16 specifically promotes p105 phosphorylation."

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"USP16 specifically promotes p105 phosphorylation."

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"In these reconstituted USP16 -/- fibroblasts, USP16 WT, but not USP16 CI, rescued the phosphorylation of p105 and the interaction between IKKbeta and p105 (XREF_FIG)."

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"Collectively, these data indicated that the USP16 mediated deubiquitination of IKKbeta may be specifically involved in the phosphorylation and processing of p105."

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"USP16 specifically promotes p105 phosphorylation."

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"This observation raised a critical question regarding whether USP16 directly regulates IKKbeta activity or p105 phosphorylation."

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"USP16 specifically promotes p105 phosphorylation."

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"With IKKbeta K238R, USP16 silencing no longer impaired the phosphorylation of p105."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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