IndraLab

Statements

USP22 increases the amount of SNAI1. 7 / 7
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"Results revealed that USP22 overexpression promoted the EMT process and increased the expression of the EMT transcriptional factor Snail1."
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"WB showed that USP22 overexpression increased the protein level of Snail1 compared with those in NG and HG, whereas Snail1 knockdown reversed the increase in Snail1 caused by USP22 overexpression ( Fi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, USP22 deficiency reversed HG-induced renal EMT and reduced Snail1 levels, thereby reducing the accumulation of TGF-β and ECM components, such as FN, Collagen I, and Collagen Ⅳ."
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"These foundations demonstrated that USP22 could deubiquitinate Snail1 to increase Snail1 protein expression in model cells, which may aggravate renal EMT process."
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"Upregulation of USP22 can increase the expression of the ZEB1 and Snail transcription factors, significantly reduce the expression of E-cadherin at cell–cell junctions, and upregulate the expression of mesenchymal markers [143]."
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"These results indicated that USP22 silencing ameliorated renal damage in db/db mice.IHC staining and WB results showed that AAV9-USP22-RNAi adeno-associated virus downregulated Snail1 expression in ki[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 promotes EMT by stabilizing Snail expression, further affecting tubulointerstitial fibrosis98."
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