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USP3 activates H2AC20. 2 / 2

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"Based on its zinc-finger Ub-binding domain (ZnF-UBP) and a catalytic domain of the Ub-specific protease (USP) class, the ZnF-UBP domain of USP3 mediates monoubiquitinated H2A (uH2A)-USP3 interaction, which affected DNA damage response [26]."

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"The ZnF-UBP domain of USP3 mediates uH2A–USP3 interaction and USP3 inhibition leads to a delay in S phase progression and to accumulation of DNA breaks."

20685273

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USP3 activates H2AC20. 2 / 2

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