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Methyl inhibits KCNH2. 3 / 3
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"Namely, in the in vitro hERG assay using patch clamp methods, 10 μM (5.7 μg/mL) of carotegrast methyl suppressed the hERG current by 32.4%; however, the same concentration did not prolong action poten[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"17 The methyl analogues 9-11 show weak inhibition of hERG (IC 50 = 2-5 muM), which can be rationalized by their inherent structural features : a basic center with pendant aromatic and lipophilic moieties."
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"Methyl analog 27 recovered SSTR2 potency (EC 50 : 0.019 µmol/L) and reduced hERG activity (IC 50 : 5.7 µmol/L)."
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