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"TxA 2 has been shown to increase intracellular Ca 2+ in platelets XREF_BIBR, and thus its stimulatory effect on KCNQ1 and KCNE3 channels in human colonic crypts may also be Ca 2+ -mediated, since carbachol (a Ca 2+ -mediated cholinergic agonist) activated KCNQ1 and KCNE3 channels during its stimulation of Cl - secretion in mouse colon XREF_BIBR."