IndraLab

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HSP90 increases the amount of KCNQ4. 4 / 4
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"Moreover, the KCNQ4 variant protein expression was rescued by the dose-dependent expression of HSP90β."
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"Gao and colleagues compared Hsp90α and Hsp90β for controlling KCNQ4 homeostasis and found that overexpressed Hsp90β could restore KCNQ4 surface expression, although it was insufficient to rescue the function of KCNQ4 channels [29]."
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"Most importantly, HSP90β restored KCNQ4 surface expression in cells mimicking the heterozygous conditions of DFNA2 patients.Next, we performed an immunoprecipitation assay and transfected HEK293T cells with the pcDNA3.1-KCNQ4-EGFP-8xHis and pcDNA3-HA-HSP90β plasmid."
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"Rescue of KCNQ4 surface expression by HSP90."
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