IndraLab

Statements

USP14 activates ATPase. 6 / 6
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"In the presence of substrate, USP14 and Ubp6 enhance the ATPase rate, strengthen the interaction between the regulatory and the core particles and induce early gate opening."
38455765
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"A series of studies have demonstrated that Ubp6 and USP14 enhances the ATPase activity of proteasome and opens the 20S gate upon treatment with ubiquitin, ubiquitin protein conjugate or active site directed probes, such as ubiquitin aldehyde (Ubal) or ubiquitin vinyl sulfone (UbVS) (XREF_FIG A, right bottom panel) [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
32726943
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"Indeed, wild-type USP14 enhanced the ATPase activity during proteasomal degradation of Ub –Sic1 by approximately 10% relative to that of the USP14-free proteasome (Fig. 3l)."
35477760
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"What defines whether Usp14 or Rpn11 wins this competition is another interesting question for future work.Second, prior work suggests that Usp14/Ubp6 stimulate the activity of the ATPase ring and open[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35963751
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"In the presence of ubiquitylated substrates, USP14 stimulates the ATPase rate, tightens the RP–CP interface and induces early CP gate opening , as represented in states ED4USP14 and ED5USP14."
35477760
reach
"Usp14 and Ubp6 can enhance the ATPase activity of the proteasome and partially open the CP gate [52,56-58]."
28988953