IndraLab

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KCNH2 inhibits cell growth. 3 / 3
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"Interestingly, hERG, another partner of KCNE2, is expressed in gastric cancer cells but not normal gastric epithelia, and the hERG channel blocker cisapride was previously found to suppress gastric cancer cell growth by inhibiting entry into S phase from G (1) phase in the cell cycle, increasing apoptosis XREF_BIBR."
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"The study indicated that siRNA was successfully transferred to the target cells and knocked down hERG that inhibited cell growth and induced apoptosis in ATC cells in vitro."
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"To further evaluate whether silencing herg gene in SH-SY5Y cells may inhibit cell growth and proliferation, the growth curves of cells nontransfected and transfected with shRNA-herg1, shRNA-herg1/1b o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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