IndraLab

Statements

USP10 activates BECN1. 5 / 5
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"Spautin-1 has been recently reported to prevent autophagy by inhibiting the deubiquitinases USP10 and USP13, which leads to beclin 1 and Vps34 (or PI3KIII) degradation [XREF_BIBR]."
23421427
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"Spautin-1, a potent small molecule, can promote the degradation of PI3KCIII and Vps34 complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13 which target the Beclin-1 subunit of Vp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23420005
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"XREF_BIBR Spautin-1 promotes the degradation of BECN1 by inhibiting 2 USPs (ubiquitin specific peptidases), USP10 and USP13, which target BECN1."
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"The fact that USP10 also positively regulates beclin-1 and AMPK would make pharmacologic activators of USP10 particularly effective as autophagy enhancers."
33577797
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"This molecule promotes the degradation of Vps34-PI 3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin-1 subunit of Vps34 complexes."
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