IndraLab

Statements

HDL inhibits NLRP3. 3 / 3
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"HDL reduces the proinflammatory role of cholesterol crystals, nigericin, and other NLRP3 and AIM2 inflammasome agonists, and several TLR agonists, leading to a decreased production of IL-1beta and IL-6."
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"In contrast, lipids such as UFAs and HDL that inhibit NLRP3 correspondingly reduce those organelle stresses."
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"UFAs can also promote autophagy while decreasing ER stress in mouse BMDMs and peritoneal macrophages [ xref , xref ], suggesting that AMPK might be a crucial mediator for UFA and HDL inhibition of NLRP3."
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