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HDL inhibits NLRP3. 6 / 6
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"In contrast, lipids such as UFAs and HDL that inhibit NLRP3 correspondingly reduce those organelle stresses."
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"Marked low HDL cholesterolemia (usually <11 mg/dL), increased FC, decreased serum ApoA-I (<50 mg/dL) and A-II, and increased serum ApoE levels are characteristic lipoprotein profiles seen in FLD patie[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Several chemicals and models application and genetic modification methods valid the hypothesis that HDL and apoA-I could inhibit NLRP3 signaling activation to inhibit acinar cell pyroptosis and protec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, HDL prevent the accumulation of cholesterol and cholesterol crystals within cells and tissues, avoiding activation of the NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome [26]."
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"HDL reduces the proinflammatory role of cholesterol crystals, nigericin, and other NLRP3 and AIM2 inflammasome agonists, and several TLR agonists, leading to a decreased production of IL-1beta and IL-6."
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"UFAs can also promote autophagy while decreasing ER stress in mouse BMDMs and peritoneal macrophages [ xref , xref ], suggesting that AMPK might be a crucial mediator for UFA and HDL inhibition of NLRP3."
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