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USP7 inhibits KDM6B. 4 / 4
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eidos
"Additionally , JMJD3 and CLU expression was not increased by knockdown of USP7 in the FOXO6 overexpressed cells , whereas CLU expression was decreased by knockdown of JMJD3 , and USP7 expression could still be regulated by FOXO6 simultaneously ."
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"In addition, when treated with cycloheximide (CHX), a protein synthesis inhibitor, upregulation of USP7 decreased the degradation of JMJD3 (XREF_FIG E)."
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"In addition , when treated with cycloheximide ( CHX ) , a protein synthesis inhibitor , upregulation of USP7 decreased the degradation of JMJD3 ( Figure 4E ) ."
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"Impressively, our experimental data elucidated that overexpressed USP7 significantly inhibited the degradation rate of JMJD3."
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