IndraLab

Statements

PRKACA phosphorylates CACNA1H on S1107. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"Here, we identify protein kinase A (PKA) as a molecular switch that allows Gbeta(2)gammax dimers to effect voltage-independent inhibition of Ca(v)3.2 channels. Inhibition requires phosphorylation of Ser(1107), a critical serine residue on the II-III loop of the channel pore protein. S1107A prevents inhibition of unitary currents by recombinant Gbeta(2)gamma(2) dimers but does not disrupt dimer binding nor change its specificity."
19131331