IndraLab

Statements

OTUB2 activates oxidative phosphorylation. 7 / 7
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"Having demonstrated that OTUB2/SNX29P2 causes impaired glycolysis and increased OXPHOS in ovarian cancer cells, we then identified the mediator of this function."
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"Overexpression of CA9 abolished the decreases in glycolysis and lactate production and the increase in OXPHOS caused by overexpression of OTUB2 and SNX29P2 (SI Appendix, Fig. S5 G–K)."
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"OTUB2/SNX29P2 Suppresses Glycolysis and Promotes OXPHOS in Ovarian Cancer.."
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"The results of gene set enrichment analysis (GSEA) indicated that overexpression of either OTUB2 or SNX29P2 suppresses the glycolysis pathway and enhances OXPHOS activity (Fig. 4 A and B)."
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"Overexpression of either OTUB2 or CALML3 in KYSE30 cells enhanced OXPHOS, as demonstrated by elevated basal respiration, maximal respiration, and ATP production ( Figures 3 I and 3J)."
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"The results indicated that silencing OTUB2 significantly increased glycolytic capacity and lactate production and inhibited OXPHOS (Fig. 4 F–H and SI Appendix, Fig. S4 E and F)."
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"Furthermore, the increased glycolysis and decreased OXPHOS mediated by OTUB2 silencing could be effectively reversed by the expression of shRNA-resistant wild-type OTUB2 (SI Appendix, Fig. S4 G–L)."
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