IndraLab

Statements

NEFL activates ATXN3. 3 / 3
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reach
"As the heterozygous 304Q model is characterized by an increase in plasma NfL at 6 months prior to ataxia symptom onset (Wilke et al., 2020b), a deeper understanding of pre-symptomatic NfL increases in the YACQ84 SCA3 mouse model would establish opportunity for preclinical studies to use NfL as a pre-symptomatic biomarker.Cohesively, we provide evidence of NfL as a biomarker in the YACQ84 mouse, highlighting the onset and progressive increases in NfL, as well as corresponding behavioral symptoms over time."
37664882
reach
"NfL was also significantly increased in SCA patients as compared to controls (AUC = 0.91 (0.81-1.00), p <.001), including NfL increases in SCA1 and SCA3."
29737427
reach
"As the heterozygous 304Q model is characterized by an increase in plasma NfL at 6 months prior to ataxia symptom onset (Wilke et al., 2020b), a deeper understanding of pre-symptomatic NfL increases in the YACQ84 SCA3 mouse model would establish opportunity for preclinical studies to use NfL as an pre-symptomatic biomarker prior to disease onset.Cohesively, we provide significant natural history of NfL as a biomarker in the YACQ84 mouse, highlighting onset and progressive increases of NfL and behavioral symptoms over time."
36909535