IndraLab

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SIRT1 inhibits mutated ATXN3. 2 / 2

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"In addition, SIRT1 overexpression induced a decrease of mutant ataxin-3, which was prevented by chloroquine (XREF_FIG)."

27165717

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"Altogether, these results suggest that SIRT1 overexpression decreases accumulation and aggregation of mutant ataxin-3 in intranuclear inclusions and decreases the levels of toxic fragments, contributing to the decrease of mutant ataxin-3 toxicity."

27165717

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IndraLab

Statements

SIRT1 inhibits mutated ATXN3. 2 / 2

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