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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SIRT1 inhibits mutated ATXN3. 2 / 2

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"In addition, SIRT1 overexpression induced a decrease of mutant ataxin-3, which was prevented by chloroquine (XREF_FIG)."

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"Altogether, these results suggest that SIRT1 overexpression decreases accumulation and aggregation of mutant ataxin-3 in intranuclear inclusions and decreases the levels of toxic fragments, contributing to the decrease of mutant ataxin-3 toxicity."

27165717

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...