IndraLab

Statements

NP binds USP22. 5 / 5
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"We demonstrated that SARS-CoV-2 NP proteins undergo ubiquitination-dependent degradation in host cells, while USP22 interacts with SARS-CoV-2 NP and downregulates K63-linked polyubiquitination of SARS-CoV-2 NP, thereby protecting SARS-CoV-2 NP from degradation."
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"In summary, these findings indicated that the host deubiquitinase USP22 can interact with SARS-CoV-2-encoded NP proteins."
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"In this study, we provide evidence that SARS-CoV-2 NP interacts with the deubiquitinase USP22 in host cells, which downregulates SARS-CoV-2 NP ubiquitination."
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"Furthermore, by immunoprecipitation, we revealed the interaction between USP22 and SARS-CoV-2 NP."
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"Additionally, there was a constitutive interaction between endogenous USP22 and SARS-CoV-2 NP ( xref )."
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