IndraLab

Statements

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits IRF3. 2 / 2
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"Inhibition of HDAC6 activity by trichostatin A (TSA), a universal HDAC inhibitor, did not impair IRF-3 activation by TLR3 signaling, as measured by its specific phosphorylation, although, as expected, IFIT1 induction was inhibited (XREF_FIG)."
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"Additionally, FMT restores immune homeostasis via providing specific colonies of bacteria which produce SCFAs (e.g., butyrate, etc.) with histone deacetylases inhibitory (HDACi) activity that can be amplified in inflammation and infection-induced systemic immune response, thereby restoring the interferon regulatory factor 3 (IRF3) signaling pathway [50]."
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