IndraLab

Statements

USP13 is phosphorylated on S114. 6 / 6
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"Specifically, Esposito et al. found that Aurora kinase B, crucial for mitosis, phosphorylates USP13 at the serine 114 and that this phosphorylation enhances the interaction of both proteins, thereby maintaining the stability of Aurora kinase B. Intriguingly, USP13 stabilizes Aurora kinase B by modulating its ubiquitination, a process that occurs independently of its DUB activity."
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"Studies have shown that Aurora B phosphorylates USP13 at Ser114 and promotes its interaction with USP13."
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"Aurora B also phosphorylates USP13 at Ser114 to promote the interaction between them and stabilizes the expression of Aurora B ( xref )."
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"Aurora B and ataxia telangiectasia mutated (ATM) regulate the expression of USP13 via phosphorylation of USP13 at Ser114 and Thr196 to promote the interaction between them, respectively, while the CDC-like kinase 3 (CLK3)-Q607R mutation induces the phosphorylation of USP13 at Tyr708 and promotes its association with c-Myc ( xref )."
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"Additionally, kinase Aurora B induced phosphorylation of the Ser114 residue in USP13 prevents several major human cancers by promoting its interaction with partners and stability ( xref )."
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"Aurora B phosphorylates USP13 at Serine 114, prompting their interaction between USP13 and Aurora, showing a potential direct link between abnormalities occurring during the cell cycle and USP13 in several human cancers [ xref ]."
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