IndraLab

Statements

USP11 activates PPP1CA. 9 / 9
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"USP11 promotes CRC progression by stabilizing the protein phosphatase 1 catalytic subunit alpha (PPP1CA) via deubiquitination."
35884607
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"USP11 is involved in the development and progression of multiple tumors XREF_BIBR - XREF_BIBR, and we have found that USP11 could promote CRC by stabilizing PPP1CA through deubiquitination XREF_BIBR."
33758608
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"USP11 promoted tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA, suggesting USP11 is a potential prognostic marker."
31521612
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"In colorectal cancer, USP11 promotes tumor growth and metastasis via the ERK/MAPK pathway by stabilizing PPP1CA [18]."
39910602
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"USP11 promotes colorectal cancer growth and metastasis by stabilizing PPP1CA, activating the ERK/MAPK pathway, and insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) signaling (151), and interacting with nuclear factor 90 (NF90) to promote HCC proliferation and metastasis (152)."
35445731
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"The findings of the present study contribute to the search for novel biomarkers related to the RAS/RAF/MAPK pathway, and may provide useful information regarding the best strategy for mCRC treatment and may improve the prognosis of patients with advanced stage CRC.In summary, the present study demonstrated that USP11 activated the ERK/MAPK signaling pathway by stabilizing PPP1CA during the development of CRC."
31521612
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"USP11 promotes tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA[66,67]."
38292842
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"Another study has the same point, namely, that the overexpression of USP11 promotes metastasis of CRC cells both in vitro and in vivo by activating the ERK/MAPK pathway and stabilizing PPP1CA."
38339403
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"Interestingly, the findings of another study indicated that USP11 promotes growth and metastasis by stabilizing PPP1CA in colorectal cancer, suggesting that DUBs could have opposite functions via regulating different proteins in diverse diseases25."
37151889