IndraLab

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"Initially, E2F1 functions downstream of RELA, while in the later phase, its activity appears to be downregulated through a TGFB1-PAX8 signaling axis (Chaves-Moreira et al, xref ; Li et al, xref )."

"DNA Binding Activity of Pax8 to the NIS Promoter Is Reduced by Smad3. TGF-β decreases Pax8 DNA binding to the NIS promoter and also found a physical interaction between Pax8 and Smad3."