IndraLab

Statements

Reactive oxygen species inhibits TLR7. 5 / 5
| 5
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"Exogenous oxidants can reduce IFN‐α production by pDC, while mitochondrial reactive oxygen species can inhibit TLR7 function48, 49; hence, oxidative stress might be a factor constraining virus‐induced IFN production."
34868584
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"Mechanistically, TLR7 induced Nox2 derived endosomal ROS negatively regulated TLR7 on the cysteine residue Cys 98 in a negative feedback loop and therefore dampened the antiviral response."
| PMC
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"The internalization of viruses specifically triggered production of hydrogen peroxide within endosomes, where NOX2-dependent production of ROS suppressed antiviral signaling networks via modification of Toll-like receptor-7 (30)."
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"Exogenous oxidants can reduce IFNa production by pDC, while mitochondrial reactive oxygen species can inhibit TLR7 function 48, 49 ; hence, oxidative stress might be a factor constraining virus-induced IFN production."
34868584
reach
"The specific mechanism is still unclear, but some people believe that the internalization of the virus triggers the production of cellular hydrogen peroxide, and the NOX2-dependent ROS production inhibits the antiviral signaling network by modifying the Toll-like receptor 7 (63)."
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