IndraLab

Statements

LINC00665 increases the amount of UCHL3. 5 / 5
| 5
reach
"LINC00665 sponges miR-582-5p to up-regulate UCHL3 expression."
35918714
reach
"Meanwhile, Western blot analysis unraveled that LINC00665 overexpression alone led to up-regulated protein levels of UCHL3, AhR and PD-L1 in tumor tissues from irradiation-treated tumor-bearing mice, and its combination with AhR silencing led to relatively decreased protein levels of AhR and PD-L1 and almost unchanged UCHL3 expression (Fig. 7D)."
35918714
reach
"Mechanistic investigations further manifested that LINC00665 functioned as a sponge of miR-582-5p and thus up-regulated UCHL3 levels."
35918714
reach
"Taken together, experimental data from the present study delineated that LINC00665 acted as a miR-582-5p sponge to up-regulate UCHL3 levels, and enhanced the stability of AhR protein, thereby reducing the radiosensitivity and promoting the immune escape in NSCLC cells."
35918714
reach
"LINC00665 functioned as a sponge of miR-582-5p and thus up-regulated the expression of the miR-582-5p target UCHL3."
35918714