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"By contrast, the proinflammatory mediators IL-1beta (which originates from helper CD4 T lymphocytes, monocytes, macrophages and endothelial cells), and LTD 4 (another eicosanoid inflammatory mediator), both of which stimulate Cl - secretion in non inflamed mammalian colon XREF_BIBR, XREF_BIBR, failed to stimulate KCNQ1 and KCNE3 channel activity in control crypts, due to either the acute nature of our experiments, or the non involvement of KCNQ1 and KCNE3 channels in the Cl - -secretory effects of IL-1beta and LTD 4."