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SGH inhibits USP28. 4 / 4
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"In terms of the mechanism, SGH inhibits USP28 and downregulates the important cancer transcription factor c-MYC by downregulating the cell cycle and nucleotide synthesis-related proteins to block the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"All data together indicated that the downregulation of c-Myc, HK2, PKM2, LDHA, PHGDH, PSAT1, cyclin D1, and CDK6 in lung cancer cells was related to the ubiquitin protein degradation pathway, which was the result that the USP28 was inhibited by SGH."
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reach
"In terms of mechanism of action, SGH downregulated cell cycle- and nucleotide synthesis related proteins to block cell cycle at G0/G1 phase, reduced the expression levels of glycolytic metabolic enzymes to inhibit glycolysis, and downregulated the important cancer transcription factor c-Myc and the therapeutic target deubiquitinase USP28."
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eidos
"All data together indicated that the downregulation of c-Myc , HK2 , PKM2 , LDHA , PHGDH , PSAT1 , cyclin D1 , and CDK6 in lung cancer cells was related to the ubiquitin-protein degradation pathway , which was the result that the USP28 was inhibited by SGH ."
33572615