IndraLab

Statements

OTUB2 binds U2AF2. 14 / 14
| 8 6
sparser
"Then the interaction between OTUB2 and U2 small nuclear RNA auxiliary factor 2 (U2AF2) was found through the immunoprecipitation method."
35309903
reach
"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2."
30662561
reach
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells."
30662561
reach
"These data collectively suggest that OTUB2 interacts with and stabilizes U2AF2 in NSCLC cells."
30662561
reach
"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
30662561
reach
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
sparser
"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells (Figure xref D)."
30662561
reach
"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
30662561
reach
"One approach, using point mutants of these proteins that specifically disrupt the U2AF2 and OTUB2 interaction, may deepen our understanding of the OTUB2 regulation of U2AF2."
30662561
sparser
"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
30662561
sparser
"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
30662561
sparser
"The interaction between OTUB2 and U2AF2 was verified by co-immunoprecipitation assays in HA-OTUB2-H292 cells (Figure xref B)."
30662561
sparser
"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2 (Figure xref C)."
30662561
reach
"The interaction between OTUB2 and U2AF2 was verified by co-immunoprecipitation assays in HA-OTUB2-H292 cells."
30662561