IndraLab

Statements

OTUB2 binds U2AF2. 20 / 20
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"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2 (Figure xref C)."
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"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells (Figure xref D)."
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"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
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"The interaction between OTUB2 and U2AF2 was verified by co-immunoprecipitation assays in HA-OTUB2-H292 cells (Figure xref B)."
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"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
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"Similarly, in non-small cell lung cancer, OTUB2 could bind to U2AF2 and deubiquitinate it, making U2AF2 more stable, promoting the Warburg effect of tumors through the AKT/mTOR signaling pathway [54]."
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"Then the interaction between OTUB2 and U2 small nuclear RNA auxiliary factor 2 (U2AF2) was found through the immunoprecipitation method."
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No evidence text available
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"The interaction between OTUB2 and U2AF2 was verified by co-immunoprecipitation assays in HA-OTUB2-H292 cells."
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"In addition, immunoprecipitation assays using an antibody against endogenous OTUB2 revealed endogenous interactions between OTUB2 and U2AF2."
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No evidence text available
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No evidence text available
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"Similarly, in non-small cell lung cancer, OTUB2 could bind to U2AF2 and deubiquitinate it, making U2AF2 more stable, promoting the Warburg effect of tumors through the AKT/mTOR signaling pathway [ xref ]."
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No evidence text available
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"Our data provide ample evidence to demonstrate that OTUB2 binds to U2AF2, efficiently deubiquitinating it by removing the K-48 polyubiquitin chains and protecting it from proteasomal degradation."
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"One approach, using point mutants of these proteins that specifically disrupt the U2AF2 and OTUB2 interaction, may deepen our understanding of the OTUB2 regulation of U2AF2."
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"Furthermore, the interaction between endogenous OTUB2 and U2AF2 was demonstrated by co-immunoprecipitation using an antibody against endogenous U2AF2 in A549 and H1299 cells."
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"These results indicate that OTUB2 specifically interacts with U2AF2 in NSCLC cells."
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"These data collectively suggest that OTUB2 interacts with and stabilizes U2AF2 in NSCLC cells."
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"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
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