IndraLab

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PKP3 increases the amount of OTUB1. 5 / 5
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"PKP3 upregulates OTUB1 expression by increasing OTUB1 mRNA stability."
34416901
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"Another study revealed that circIGF2BP3 functioned as the molecular sponge of miR-328-3p and miR-3173-5p to upregulate plakophilin 3 (PKP3) expression, thereby increasing ovarian tumor (OTU) family deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) level and facilitating PD-L1 deubiquitination [8]."
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"Taken together, these findings indicate that PKP3 upregulates OTUB1 expression at the posttranscriptional level rather than at the transcriptional level, possibly by increasing the stability of OTUB1 mRNA."
34416901
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"31 Competitive binding of miR‐328‐3p and miR‐3173‐5p to circIGF2BP3 results in the upregulation of PKP3 expression, which promotes deubiquitinating enzyme otubain‐1 (OTUB1) expression by increasing its mRNA stability, and then prevents the proteasomal degradation of programmed cell death 1 ligand 1 (PD‐L1) by inducing its deubiquitination, and ultimately inhibits the activation and infiltration of CD8 T cells in the tumor region and thus facilitates tumor immune evasion in NSCLC."
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"In line with this, we showed that PKP3 did not influence OTUB1 transcription but altered the rate of OTUB1 mRNA turnover, as demonstrated by actinomycin treatment (Fig. 7A-B)."
34416901