IndraLab

Statements

ML364 inhibits USP2. 11 / 11
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"Given that ML364 inhibits USP2, we next investigated the role of USP2 in antithrombin turnover."
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"We demonstrated that pharmacological inhibition of USP2 by ML364 prominently reduced the formation of TNBC tumorspheres in a dose dependent fashion."
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"Moreover, USP2 inhibition by ML364 considerably enhanced the cytotoxicity of doxorubicin or paclitaxel in multiple TNBC cell models."
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"We reasoned that while ML364 inactivated USP2 catalytic activity, this small molecule is unlikely to disrupt the USP2–SKP2 binding, leading to less “free” SKP2 to degrade its substrates."
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"USP2 overexpression promoted proliferation and metastasis, and induced the EMT in CM cells in vitro, while specific inhibition of USP2 by ML364 produced the opposite effects."
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"In support of this notion, USP2 inhibition by ML364 led to a dose dependent reduction in Twist and Bmi1 expression."
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"ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) in human breast cancer (Davis et al., 2016)."
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"The small-molecular inhibitor of USP2, ML364, was purchased from TargetMol."
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"Together, these observations provide compelling evidence that ML364, by inhibiting USP2 and subsequently reducing ACE2 protein, effectively counteracts SARS-CoV-2 infection both in vitro and in vivo."
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"However, the commercially available inhibitors for these DUBs had no obvious influence on the SOX2 expression, including b-AP15 (the inhibitor of USP14 and UCHL5), P5091 (the inhibitor of USP7 and USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, these results confirmed the ACE2 dependency in the inhibition of USP2 by ML364 or MS102, thereby resulting in their inhibitory effects on viral infections."
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