IndraLab

Statements

Cisplatin activates USP7. 8 / 8
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"An intricate study revealed that cisplatin and paclitaxel activate USP7, prompting CAFs to emit exosomal miR-522."
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"There is a study that suggested that cisplatin and paclitaxel promote miR-522 secretion from cancer-associated fibroblasts by activating the USP7/hnRNPA1 axis, leading to arachidonate lipoxygenase 15 suppression and decreased lipid-ROS accumulation in cancer cells, and ultimately resulting in decreased chemo-sensitivity [37]."
| PMC
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"Haiyang Zhang et al. found that cisplatin and paclitaxel promote miR-522 secretion from CAFs by activating the USP7/hnRNPA1 axis."
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"Paclitaxel and cisplatin promote miR-522 secretion from cancer-associated fibroblasts by activating USP7/hnRNPA1 axis, leading to arachidonate lipoxygenase 15 suppression and decreased lipid-ROS accumulation in cancer cells and ultimately promote acquired chemoresistance in gastric cancer (Zhang et al., 2020a)."
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"Importantly, cisplatin and paclitaxel promote miR-522 secretion from CAFs by activating USP7/hnRNPA1 axis, leading to ALOX15 suppression and decreased lipid-ROS accumulation in cancer cells, and ultimately result in decreased chemo-sensitivity."
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"Cisplatin also activates ubiquitin-specific protease 7 (USP7), which stabilizes heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) by deubiquitination [ 236 ]."
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"Cisplatin and paclitaxel activated the USP7/hnRNPA1 axis to upregulation of RNPA1 protein expression in GC cells."
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"An intricate study revealed that cisplatin and paclitaxel activate USP7, prompting CAFs to emit exosomal miR-522 ."
38702734