IndraLab

Statements

USP9X deubiquitinates SMAD4. 17 / 18
1 | 17
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"Subsequently it was shown that USP9X deubiquitylates SMAD4 that is monoubiquitylated at K519 (XREF_FIG)."
25007997
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"This inhibitory event is readily reversed by FAM and USP9x, which deubiquitinates Smad4 and restores its responsiveness to TGF-beta [XREF_BIBR]."
20940046
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"FAM and USP9X is required for TGFbeta induced migration of MDA-MB-231 breast cancer cells; mechanistically, FAM and USP9X inhibits the monoubiquitination of SMAD4, a modification that blocks the association of SMAD4 with phospho-SMAD2 [XREF_BIBR] (XREF_FIG)."
27844253
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"Usp9x deubiquitylation of Smad4 is essential for signalling by members of the Tgf-beta family XREF_BIBR, XREF_BIBR."
23861879
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"USP9X (also known as FAM) deubiquitylates SMAD4 and thereby sustains TGF-beta signaling (Dupont etal."
26085183
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"The ubiquitin ligase Ectodermin/TIF1γ promotes, while the deubiquitinases USP9X and USP4 antagonize SMAD4 monoubiquitination [28,85,86]."
35682605
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"For example USP9X may upregulate ID2 gene expression by deubiquitinating and stabilizing the transcription factor SMAD4 (Dupont et al., 2009)."
21925315
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"USP9X reverses Smad4 ubiquitination to reactivate the pathway and reinstate TGFbeta signaling."
25606592
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"The deubiquitination of Smad4 by FAM is direct."
19135894
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"Dupont et al. (2009) now demonstrate that FAM deubiquitinates Smad4 that has been monoubiquitinated by Ecto/TIF1γ."
19135880
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"In the cytoplasm, FAM and Usp9x deubiquitinates and recycles Smad4, re-empowering its competence to mediate TGFbeta signaling.We identified in Ecto a critical factor for Smad4 monoubiquitination at ly[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19135894
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"However, FAM/USP9x can reverse the ubiquitination of Smad4 and counteract the activity of TIF1γ in TGF-β/Smad signaling (30)."
31632911
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"Usp9x promotes TGFbeta pathway signalling by deubiquitylating Smad4, allowing it to complex with phosphorylated receptor Smads and then shuttle into the nucleus to execute transcriptional responses to TGFbeta family ligands [XREF_BIBR]."
25672900
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"Similarly, USP9x and USP11 interact and deubiquitinate Smad4 and ALK5, respectively, [29, 30] to regulate the transforming growth factor/BMP cell signaling pathways necessary for osteogenic differentiation and bone formation."
35273362
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"USP9x deubiquitinates Smad4, activating the signaling pathway, but it does not stabilize the protein."
33577811
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"Taken together, these results demonstrate that USP9x selectively binds to SMAD4 in competition with TIF1gamma and deubiquitinates SMAD4, promoting nuclear SMAD4 retention, SMAD3 and SMAD4 complex formation and target gene expression."
28115363
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"USP9X deubiquitinates Smad4 and facilitates it bind to phospho-Smad 2 and translocate to the nucleus, which promotes TGF-β/Smad pathway activation [ 16 ]."
32442538