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BAP1 inhibits H2Aub. 10 / 10
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"This scenario is possible because H2Aub levels at a DSB are inversely correlated with BAP1 recruitment , and BAP1 depletion increases H2Aub accumulation at a DSB (Fig. 1)."
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"Genomic analyses together with robust statistics have revealed that the restoration of BAP1 facilitates the formation of the polycomb repressive deubiquitinase (PR-DUB) complex and inhibits ubiquitinated histone 2A (H2Aub) occupancy on the SLC7A11 promoter."
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"BRCA1-associated protein 1 (BAP1) negatively regulated H2Aub to decrease SLC7A11 expression, leading to lipid peroxidation accumulation."
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"Analysis of our H2Aub ChIP-seq data revealed that restoration of BAP1 WT, but not BAP1 C91A, markedly decreased H2Aub occupancy at both the promoter and gene body of SLC7A11 (XREF_FIG), which was further confirmed by H2Aub ChIP assay on the SLC7A11 promoter and representative exons (XREF_FIG and XREF_SUPPLEMENTARY)."
30202049
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"Our own findings suggest that BAP1 inhibition leads to increased level of H2Aub , which interferes with chromatin and histone modifications at double-strand breaks ."
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"Several studies have revealed that BAP1 can inhibit ubiquitinated histone 2A (H2Aub) occupancy on the SLC7A11 promoter (Zhang et al., 2018)."
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"Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB) and BAP1 complex."
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"For example, BAP1 has been found to reduce H2Aub occupancy of the SLC7A11 promoter, leading to the suppression of SLC7A11 expression and contributing to elevated ferroptosis and lipid peroxidation [60]."
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"The combination of H2Aub and SLC7A11 promoter was detected by ChIP with H2Aub antibody or lgG, and qPCR and agarose gel electrophoresis showed that H2Aub could directly bind to SLC7A11 promoter, overexpressing BAP1 could reduce H2Aub enrichment on SLC7A11 promoter (Fig. 1E–F)."
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"As a tumor suppressor, BAP1 can target SLC7A11, reduce the H2Aub occupancy on the SLC7A11 promoter, inhibit the function of the amino acid transport complex system Xc-, and induce cancer cell death by promoting lipid peroxidation in cancer cells [16]."
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