IndraLab

Statements

Fingolimod hydrochloride inhibits NLRP3. 5 / 5
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"The in vitro experiments also revealed FTY720 could suppress M1 marker expressions and NLRP3 inflammasomes and promote M2 marker expressions."
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"Consistently, the results of western blotting analysis showed that FTY720 treatment attenuated OGD-induced the increases of NLRP3 inflammasome and M1 markers (iNOS, CD11b, Cox-2, and Pre-IL1β) and the decreases of M2 markers (CD206 and IGF-1α) in microglia, confirming that FTY720 could directly promote microglial polarization to M2 phenotype (Figure 3E)."
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"The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production."
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"Consistently, western blot analysis showed that FTY720 prevented MCAO-induced the increase of Iba1, iNOS, and NLRP3 and the reduction of TREM2 (Figures 2G–J)."
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"The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1β production."
30802544