IndraLab

Statements

ATXN3 decreases the amount of ATXN3. 5 / 5
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"Indeed, exogenous FBXL3 in SCA3 NPCs reduced the levels of both wild-type and pathogenic ATXN3 in a SCF dependent manner."
31783119
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"A limitation of the study was that only si-ATXN3 was used to downregulate the expression of ATXN3."
30942397
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"ATXN3 associated with CK2alpha and pharmacological inhibition of CK2 decreased nuclear ATXN3 levels and the formation of nuclear inclusions."
19542537
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"The simultaneous upregulation of closely related miRNAs targeting the 3 ' UTR of ATXN3 correlates with significantly reduced ATXN3 expression levels in SCA3-LCs suggesting that members of the miR-25 and miR-181 family cooperatively bind to the 3 ' UTR of ATXN3 to suppress the expression of ATXN3 in SCA3-LCs."
30147021
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"Consequently, si-ATXN3 significantly decreased ATXN3 and Bax protein expression and increased cyclin D1 protein expression in colon cancer cells compared with the miR-25 downregulation group (Fig. 6)."
30942397