IndraLab

Statements

Smo-1 inhibits ATXN3. 5 / 5
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"These findings, together with the effects of the autophagy inhibitor 3-MA, led us to speculate as to whether autophagy-lysosome system plays more important role in SUMO induced ataxin-3 degradation."
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"On the other hand, the observation that MG132 blocked SUMO induced degradation of ataxin-3, although the effect was not strong, suggested a role of UPS for this process."
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"In the future studies, different substitutions should be designed and tested to confirm the requirement of SIM for SUMO induced degradation of ataxin-3."
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"Proteolytic pathways mediating SUMO induced ataxin-3 degradation."
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"Interestingly, the autophagy inhibitor 3-MA reduced SUMO induced degradation of ataxin-3 much more effectively."
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