IndraLab

Statements


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"Mechanistic studies have shown that stable Y-box binding protein 1 (YB-1) contributed to USP47-mediated DNA damage repair in CML cells."

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"USP47 overexpression in YB-1 and/or Polbeta depletion cells can not abrogate gammaH 2 AX expression, indicating that YB-1 contributes more to USP47 mediated DNA damage repair than Polbeta in CML cells."

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"The results indicate that YB-1 is involved in USP47 mediated DNA damage repair in CML cells."

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"We further demonstrated that YB-1, a novel substrate of USP47, contributes to USP47 mediated DNA damage repair."

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"To assess the contribution of YB-1 and Polbeta to USP47 mediated DNA damage repair in CML cells, we overexpressed USP47 in YB-1 and/or POLB knockdown K562 and KBM5 T315I cells."

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"YB-1 contributes to USP47 mediated DNA damage repair in CML cells."

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"Taken together, these data demonstrate that by controlling stability of the cytoplasmic form of Pol beta, USP47 modulates the efficiency of DNA damage repair by the BER pathway and maintains genome in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"As a substrate of USP47, YB-1 contributes to USP47 mediated DNA damage repair in CML cells."

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"Mechanistic studies show that stabilizing Y-box binding protein 1 contributes to USP47 mediated DNA damage repair in CML cells."