IndraLab

Statements

ATXN3 decreases the amount of STUB1. 3 / 3
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"SCA3 transgenic mice have significantly decreased CHIP levels, while ataxin-3 knockout mice have no difference in CHIP levels compared to wild-type mice [53]."
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"Importantly, ataxin-3 deubiquitinates CHIP, terminating CHIP-substrate interaction; polyQ expansion of ataxin-3 increases its affinity for CHIP and decreases CHIP levels in SCA3 mice, suggesting a surprising role for coordinated regulation of CHIP and ataxin-3 as well as dysregulation of this process in SCA3."
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"Moreover, ataxin-3 also induces a reduction in CHIP levels."
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